by Bita Moghaddam

The emergence of ketamine—previously known as a combat anesthetic and club drug—as a treatment for depression.

Ketamine, approved in 2019 by the Food and Drug Administration for the treatment of depression, has been touted by scientists and media reports as something approaching a miracle cure. This volume in the MIT Press Essential Knowledge series chronicles the ascent of a drug that has been around for fifty years–in previous incarnations, a Vietnam-era combat anesthetic and a popular club drug–that has now been reinvented as a treatment for depression. Bita Moghaddam, a leading researcher in neuropharmacology, explains the scientific history and the biology of ketamine, its clinical use, and its recently discovered antidepressant effects, for the nonspecialist reader.

Paperback | 208 pages | The MIT Press | 2021

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